Species: Hu, Mu, Rt
Applications: ICC/IF, IHC, ChIP
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt, Bv, RM
Applications: WB, ICC/IF, IHC, IP
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB, IHC
Host: Mouse monoclonal
Species: Hu
Applications: WB
Species: Hu
Applications: AC
Description
Transcriptional control is in part regulated by interactions between DNA-bound transcription factors, such as Egr-1/NGFI-A, and coregulatory proteins, such as NAB (for NGFI-A-binding proteins). The evolutionarily conserved NAB proteins, NAB1 and NAB2, are corepressors of EGF-1/NGFI-A. Both NAB1 and NAB2 contain an amino terminal NAB conserved domain 1 (NCB1), which is required for binding NGFI-A, and a carboxy terminal NCD2 domain, which is responsible for the repressor function of NAB proteins. NAB2 is principally localized in the nucleus and may play a role in the downregulation of NGFI-A activity as well as in controlling fundamental processes such as cell division, differentiation and apoptosis. NAB2 has a predicted molecular mass of 56 kDa and localizes to chromosome 12q13.3-14.1, a region that is rearranged in several solid tumors, lipomas and liposarcomas.
Bioinformatics
| Uniprot |
Human
Human
Human
Human
|
| Product By Gene ID |
4665 |
| Alternate Names |
- EGR-1-binding protein 2
- MADEREGR1 binding protein 2
- Melanoma-associated delayed early response protein
- MGC75085
- NGFI-A binding protein 2 (EGR1 binding protein 2)
- NGFI-A-binding protein 2
- Protein MADER
|
