MTBP Products

Description

The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several molecules involved in p53 network, including Chk2, p53R2, p53AIP1, Noxa, PIDD, PID/MTA2, and MTBP, were recently discovered. The transcriptional activity of p53 is modulated by posttranslational regulations of the p53 protein including stabilization and acetylation. P53 transcriptionally activates MDM2 gene then the translated MDM2 protein binds to p53 and promotes the degradation of p53 leading to lowering the concentration of p53 protein. MDM2 inhibits both p53 mediated G1 arrest and apoptosis. A recently discovered protein termed MTBP was found to bind to MDM2 and to inhibit the modulation effect of MDM2 on p53. MTBP is expressed in a variety of normal tissues.

Bioinformatics

Entrez	27085 Human
Uniprot	NP_071328 Human Q96DY7 Human
Product By Gene ID	27085
Alternate Names	hMTBP MDM2 (mouse double minute 2)-binding protein, 104kD Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) bindingprotein, 104kDa mdm2-binding protein MDM2BP

Research Areas for MTBP

Find related products by research area and learn more about each of the different research areas below.

Cancer
DNA Repair