MTBP Products

Antibodies
MTBP Antibody
MTBP Antibody
NBP1-86408
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
MTBP Antibody
MTBP Antibody
NBP1-76747
Species: Hu
Applications: WB, ELISA, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
MTBP Antibody
MTBP Antibody
NBP2-19427
Species: Hu
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
MTBP Overexpression Lysate (N ...
MTBP Overexpression Lysate (Native)
NBP2-06485
Applications: WB
Proteins
MTBP Recombinant Protein Anti ...
MTBP Recombinant Protein Antigen
NBP2-55351PEP
Species: Hu
Applications: B/N, Ctrl
MTBP Recombinant Protein Anti ...
MTBP Recombinant Protein Antigen
NBP1-86408PEP
Species: Hu
Applications: AC
MTBP Blocking Peptide
MTBP Blocking Peptide
NBP1-76747PEP
Species: Hu
Applications: AC

Description

The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several molecules involved in p53 network, including Chk2, p53R2, p53AIP1, Noxa, PIDD, PID/MTA2, and MTBP, were recently discovered. The transcriptional activity of p53 is modulated by posttranslational regulations of the p53 protein including stabilization and acetylation. P53 transcriptionally activates MDM2 gene then the translated MDM2 protein binds to p53 and promotes the degradation of p53 leading to lowering the concentration of p53 protein. MDM2 inhibits both p53 mediated G1 arrest and apoptosis. A recently discovered protein termed MTBP was found to bind to MDM2 and to inhibit the modulation effect of MDM2 on p53. MTBP is expressed in a variety of normal tissues.

Bioinformatics

Entrez Human
Uniprot Human
Human
Product By Gene ID 27085
Alternate Names
  • mdm2-binding protein
  • MDM2BP
  • hMTBP
  • MDM2 (mouse double minute 2)-binding protein, 104kD
  • Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) bindingprotein, 104kDa

Research Areas for MTBP

Find related products by research area and learn more about each of the different research areas below.

Cancer
DNA Repair

PTMs for MTBP

Learn more about PTMs related to MTBP.

Ubiquitination
Acetylation

Bioinformatics Tool for MTBP

Discover related pathways, diseases and genes to MTBP. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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