MRCL3 Products

Antibodies
MRCL3 Antibody
MRCL3 Antibody
NBP2-46856
Species: Hu, Mouse, Rat
Applications: IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
MRCL3 Overexpression Lysate ( ...
MRCL3 Overexpression Lysate (Native)
NBL1-13218
Applications: WB
Proteins
MRCL3 Recombinant Protein
MRCL3 Recombinant Protein
NBP1-72407
Species: Hu
Applications: PAGE
RNAi
MRCL3 RNAi
MRCL3 RNAi
H00010627-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

The muscle myosins and hexomeric proteins consisting of two heavy chains and two pairs of light chains, the latter called essential (ELC) and regulatory (RLC). The light chains stabilize the long alpha helical neck of the myosin head (1). Human myosin light chain-2 (MYL2) is an important protein involved in the regulation of myosin ATPase activity in smooth muscle. In cardiac muscle, the precise role of MYL2 is not well understood; however, an increase in ventricular MYL2 is observed during myocardial hypertrophy in cardiac patients with valve stenosis (2). Familial hypertrophic cardiomyopathy (FHC) is an autosomal dominant disease caused by mutations in all of the major sarcomeric proteins, including the ventricular myosin regulatory light-chain (RLC). The Myosin RLC mutation has been associated with a rare variant of cardiac hypertrophy defined by mid-left ventricular obstruction due to papillary muscle hypertrophy. This mutation was later found to cause ventricular and septal hypertrophy (3).

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Product By Gene ID 10627
Alternate Names
  • RLC
  • Myosin regulatory light chain 2, nonsarcomeric
  • myosin regulatory light chain MRCL3
  • myosin, light polypeptide, regulatory, non-sarcomeric (20kD)
  • myosin regulatory light chain 3
  • MYL2B
  • myosin regulatory light chain 12A
  • MRCL3
  • MRLC3MLC-2B
  • MLCBMyosin RLC
  • Myosin regulatory light chain MRLC3
  • myosin, light chain 12A, regulatory, non-sarcomeric

Diseases related to MRCL3

Discover more about diseases related to MRCL3.

Adenocarcinoma
Malignant Neoplasms
Colonic Neoplasms
Malignant Tumor Of Colon
Tissue Adhesions

Pathways for MRCL3

View related products by pathway and learn more about each of the pathways below.

Senescence
Cell Adhesion

PTMs for MRCL3

Learn more about PTMs related to MRCL3.

Phosphorylation

Bioinformatics Tool for MRCL3

Discover related pathways, diseases and genes to MRCL3. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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