MPRA Products

Description

The steroid progesterone induces the resumption of maturation in oocytes via a nongenomic pathway through binding to a novel, membrane progestin receptor (mPR). This pathway inhibits adenylyl cyclase and reduces intracellular cAMP, and also activates mitogen-activated protein kinase to effect signal transduction pathways. Three distinct groups, designated alpha, beta and gamma, comprise this gene family. mPRalpha, also designated progestin and adipoQ receptor family member VII (PAQR7), consists of an extracellular N-terminus, an intracellular C-terminus, and seven transmembrane domains. It is expressed in ovary, testis, placenta, uterus and bladder. mPRbeta, also designated progestin and adipoQ receptor family member VIII (PAQR8), consists of eight putative transmembrane regions and an intracellular N-terminus that contains a leucine-rich motif. It is a 354 amino acid protein with a molecular mass of about 40 kDa and is expressed in brain and spinal cord. Both mPRalpha and mPRbeta may be G protein-coupled receptors and may be involved in oocyte maturation.

Bioinformatics

Entrez	164091 Human
Uniprot	NP_848509 Human NP_848509.1 Human Q86WK9 Human
Product By Gene ID	164091
Alternate Names	mPR alpha MRPA Progestin and adipoQ receptor family member 7 membrane progestin receptor alpha mSR MPRA2310021M12Rik progestin and adipoQ receptor family member VIIPGLP

Diseases related to MPRA

Discover more about diseases related to MPRA.

Malignant Neoplasms
Neoplasms
Tumor Progression
Malignant Neoplasm Of Breast
Malignant Neoplasm Of Ovary
Ovarian Neoplasm

Pathways for MPRA

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Glucose Homeostasis
Secretion
Hormone Secretion

PTMs for MPRA

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Phosphorylation

Bioinformatics Tool for MPRA

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