MMP21 Products

Description

Matrix metalloproteinases (MMPs) play key roles in tissue remodelling under normal development and, especially, in diseases ranging from malignancies to stroke. Expression of MMP-21 is controlled uniquely by Pax and Notch transcription factors known to be critical for organogenesis. MMP-21 is expressed transiently in mouse embryogenesis and increased in embryonic neuronal tissues. Observations indicate that there is an important specific function for MMP-21 in embryogenesis, especially in neuronal cells (1). MMP-21 is expressed in various human fetal and adult tissues as well as in cancer cell lines. MMP-21 protein can also be detected in malignancies such as ovarian and colon carcinomas by immunohistochemical staining. Findings suggest that MMP-21 functions in embryogenesis and tumor progression (2). Results suggest that during development, MMP-21 expression is temporally and spatially tightly controlled. Unlike many classical MMPs, it is present in various normal adult tissues. Among epithelial MMPs, MMP-21 has a unique expression pattern in cancer (3).

Bioinformatics

Entrez	118856 Human
Uniprot	NP_671724 Human NP_671724.1 Human Q8N119 Human
Product By Gene ID	118856
Alternate Names	EC 3.4.24 EC 3.4.24.- matrix metallopeptidase 21 matrix metalloproteinase 21 matrix metalloproteinase-21 MMP-21

Diseases related to MMP21

Discover more about diseases related to MMP21.

Malignant Neoplasms
Neoplasms
Neoplasm Metastasis
Cell Invasion
Carcinoma
Skin Neoplasms
Metastatic Malignant Neoplasm To The Lymph Node
Malignant Paraganglionic Neoplasm
Dermatologic Disorders
Tumor Progression
Cell Transformation, Neoplastic
Malignant Squamous Cell Neoplasm
Non-neoplastic Disorder
Dysplasia
Mammary Neoplasms
Colorectal Neoplasms
Inflammation
Colorectal Cancer
Invasive Malignant Neoplasm
Squamous Cell Neoplasms

Pathways for MMP21

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Keratinocyte Differentiation
Secretory Pathway
Cell Proliferation
Gastrulation
Translation
Skin Development
Angiogenesis
Pathogenesis

Research Areas for MMP21

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Breast Cancer

Bioinformatics Tool for MMP21

Discover related pathways, diseases and genes to MMP21. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.