MMP21 Products

Description

Matrix metalloproteinases (MMPs) play key roles in tissue remodelling under normal development and, especially, in diseases ranging from malignancies to stroke. Expression of MMP-21 is controlled uniquely by Pax and Notch transcription factors known to be critical for organogenesis. MMP-21 is expressed transiently in mouse embryogenesis and increased in embryonic neuronal tissues. Observations indicate that there is an important specific function for MMP-21 in embryogenesis, especially in neuronal cells (1). MMP-21 is expressed in various human fetal and adult tissues as well as in cancer cell lines. MMP-21 protein can also be detected in malignancies such as ovarian and colon carcinomas by immunohistochemical staining. Findings suggest that MMP-21 functions in embryogenesis and tumor progression (2). Results suggest that during development, MMP-21 expression is temporally and spatially tightly controlled. Unlike many classical MMPs, it is present in various normal adult tissues. Among epithelial MMPs, MMP-21 has a unique expression pattern in cancer (3).

Bioinformatics

Entrez	118856 Human
Uniprot	NP_671724 Human NP_671724.1 Human Q8N119 Human
Product By Gene ID	118856
Alternate Names	EC 3.4.24 EC 3.4.24.- matrix metallopeptidase 21 matrix metalloproteinase 21 matrix metalloproteinase-21 MMP-21

Research Areas for MMP21

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer