MMP20 Products

Antibodies
MMP20 Antibody
MMP20 Antibody
NBP1-62322
Species: Hu
Applications: WB
Host: Rabbit Polyclonal
MMP20 Antibody
MMP20 Antibody
H00009313-D01P
Species: Hu
Applications: WB, ELISA
Host: Rabbit Polyclonal
MMP20 Antibody
MMP20 Antibody
H00009313-B01P
Species: Hu
Applications: WB, ELISA
Host: Mouse Polyclonal
Lysates
MMP20 Overexpression Lysate ( ...
MMP20 Overexpression Lysate (Native)
NBL1-13156
Applications: WB
RNAi
MMP20 RNAi
MMP20 RNAi
H00009313-R01
Species: Hu

Description

MMP-20 (enamelysin) is a recently discovered member of the MMP family. This enzyme is involved in the degradation of the various components of the extracellular matrix (ECM) during development, haemostasis and pathological conditions. MMP-20 expression has been found to be restricted to the enamel organ and due to its unique expression pattern, may primarily be involved in the turnover of these molecules during tooth development. The enamel matrix proteins amelogenin, ameloblastin, and enamelin are expressed during the developmental time period, suggesting that MMP-20 may play a role in their hydrolysis (1). Recombinant human enamelysin is able to degrade amelogenin, the major protein component of the enamel matrix. On the basis of its degrading activity on amelogenin, and its highly restricted expression to dental tissues, we suggest that human enamelysin plays a central role in the process of tooth enamel formation (2). Enamelysin null mice do not process amelogenin properly, possesses an altered enamel matrix and rod pattern, has hypoplastic enamel that delaminates from the dentin, and has a deteriorating enamel organ morphology as development progresses (3).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Product By Gene ID 9313
Alternate Names
  • matrix metalloproteinase-20
  • EC 3.4.24.35
  • AI2A2
  • EC 3.4.24.22
  • MMP-20
  • EC 3.4.24
  • Enamel metalloproteinase
  • Enamelysin
  • matrix metalloproteinase 20 (enamelysin)
  • EC 3.4.24.-
  • matrix metallopeptidase 20

PTMs for MMP20

Learn more about PTMs related to MMP20.

Cleavage
Phosphorylation

Bioinformatics Tool for MMP20

Discover related pathways, diseases and genes to MMP20. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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