Species: Hu
Applications: WB
Host: Mouse Monoclonal
Species: Hu
Applications: ICC/IF
Host: Mouse Monoclonal
Species: Hu, Mu, Rt
Applications: IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: AC
Description
MIB2/Skeletrophin is an actin-binding protein that bears two MIB/HERC2 domains, a ZZ-type zinc-finger domain, nine ankyrin repeats, and two RING-finger domains. The C-terminal RING domain has been found to have E3 ubiquitin ligase activity that mediates ubiquitination of the intracellular regions of the Notch receptor and its ligands to regulate Notch signaling. MIB2/Skeletrophin appears to be important to muscle development and may function as a suppressor of melanoma invasion.
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
|
| Product By Gene ID |
142678 |
| Alternate Names |
- E3 ubiquitin-protein ligase MIB2
- EC 6.3.2
- EC 6.3.2.-
- EC 6.3.2.13
- FLJ20648
- FLJ41406
- Mind bomb homolog 2
- mindbomb homolog 2 (Drosophila)
- Novel zinc finger protein
- novelzin
- Novelzin
- Putative NF-kappa-B-activating protein 002N
- SKD
- Skeletrophin
- Zinc finger ZZ type with ankyrin repeat domain protein 1
- ZZ type with ankyrin repeat domain 1
- ZZANK1
|
Research Areas for Mind Bomb 2/MIB2
Find related products by research area and learn more about each of the different research areas below.
Signal Transduction
