Mind Bomb 2/MIB2 Products

Description

MIB2/Skeletrophin is an actin-binding protein that bears two MIB/HERC2 domains, a ZZ-type zinc-finger domain, nine ankyrin repeats, and two RING-finger domains. The C-terminal RING domain has been found to have E3 ubiquitin ligase activity that mediates ubiquitination of the intracellular regions of the Notch receptor and its ligands to regulate Notch signaling. MIB2/Skeletrophin appears to be important to muscle development and may function as a suppressor of melanoma invasion.

Bioinformatics

Entrez	142678 Human
Uniprot	AAH37542 Human
Product By Gene ID	142678
Alternate Names	EC 6.3.2.13 EC 6.3.2 Skeletrophin FLJ41406 SKD FLJ20648 Novelzin ZZANK1 EC 6.3.2.- Zinc finger ZZ type with ankyrin repeat domain protein 1 novelzin Putative NF-kappa-B-activating protein 002N E3 ubiquitin-protein ligase MIB2 Novel zinc finger protein Mind bomb homolog 2 ZZ type with ankyrin repeat domain 1 mindbomb homolog 2 (Drosophila)

Diseases related to Mind Bomb 2/MIB2

Discover more about diseases related to Mind Bomb 2/MIB2.

Malignant Paraganglionic Neoplasm
Neoplasms
Cell Invasion
Melanoma
Melanocytic Nevus
Cutaneous Melanoma
Neuroblastoma
Neoplasm Metastasis
Cell Transformation, Neoplastic
Fibromyalgia
Exencephaly
Neoplasm Invasiveness
Carcinoma
Multiple Myeloma
Oncolysis
Syndactyly
Recurrence (disease Attribute)
Myoepithelioma
Malignant Myoepithelioma

Pathways for Mind Bomb 2/MIB2

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Endocytosis
Notch Signaling Pathway
Localization
Methylation
Translation
Cell Development
Skin Development
Muscle Contraction
Cell Growth
Myoblast Fusion
Cell Fate Specification
Chromatin Remodeling

Research Areas for Mind Bomb 2/MIB2

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Signal Transduction

PTMs for Mind Bomb 2/MIB2

Learn more about PTMs related to Mind Bomb 2/MIB2.

Ubiquitination
Demethylation
Methylation

Bioinformatics Tool for Mind Bomb 2/MIB2

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