Description
Methionine (Met) oxidation is one of the most common posttranslational modifications to proteins that may alter protein structure and function. Accumulation of proteins containing methionine sulfoxide (MetO) is known to occur during oxidative stress. If the reversal of protein MetO to Met is not sufficient it may cause proteins to loose function, aggregate and be toxic to the cell. Methionine oxidation in proteins has been associated with neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and Creutzfeldt-Jakob disease.
Bioinformatics
