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MC5R, a Melanocortin Receptor, mediates the effects of melanocyte-stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH), and activates adenylate cyclase. This receptor controls multiple functions in the brain and in peripheral tissues, such as thermoregulation, immunomodulation, appetite control, and sexual behavior. Melanocortin 5 receptor has been reported to be expressed in a variety of tissues, especially in pituitary, exocrine glands, reproductive organs, lung, kidney, and esophagus. No human ESTs have been isolated.
