mDCAR1/CLEC4B2 Products

Description

CLEC4B2 (C-type Lectin domain family 4, member b2), also called dendritic cell immunoactivating receptor 1 (DCAR1) and antigen presenting cell lectin-like receptor A1 (APLRA1), is a type II membrane protein belonging to the cell surface C-type lectin domain family (1, 2). Mouse CLEC4B2 is synthesized as a 208 amino acid (aa) precursor that contains a 22 aa transmembrane segment and a 167 aa extracellular domain (ECD) containing a C-type lectin domain. The ECD of mouse CLEC4B2 shares 71% and 50% aa identity with rat CLEC4B2 ECD and human CLEC4B2 ECD, respectively. Activation of CLEC4B2 in the epidermis regulates immune defenses. CLEC4B2 potentially has a second role in host defense. CLEC4B2 is specifically required for the innate immune response to fungal infection and wounding and place this GPCR further upstream than any other known component of innate immune recognition and signaling in C. elegans epidermis.

Bioinformatics

Uniprot	Q67DU8
Alternate Names	CLEC4B2 mDCAR1