Maxi Potassium channel alpha Products

Maxi Potassium channel alpha ...
Maxi Potassium channel alpha Antibody
Species: Hu, Mu, Rt, Bv, Ca, Eq, Gp, Rb, Sh, Ze
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
Maxi Potassium channel alpha ...
Maxi Potassium channel alpha Antibody
Species: Hu, Mu, Rt
Applications: IHC, IHC-P
Host: Rabbit Polyclonal
Maxi Potassium channel alpha ...
Maxi Potassium channel alpha Antibody
Species: Mu, Rt
Applications: WB, Flow, IHC, IHC-P
Host: Rabbit Polyclonal
Maxi Potassium channel alpha ...
Maxi Potassium channel alpha Overe...
Species: Hu
Applications: WB
Maxi Potassium channel alpha ...
Maxi Potassium channel alpha Recom...
Species: Hu
Applications: AC


Function: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX). The protein was initially thought to contain two functionally distinct parts: The core channel (from the N-terminus to the S9 segment) that mediates the channel activity, and the cytoplasmic tail (from the S9 segment to the C-terminus) that mediates the calcium sensing. The situation is however more complex, since the core channel also contains binding sites for Ca(2+) and Mg(2+).; Defects in KCNMA1 are the cause of generalized epilepsy and paroxysmal dyskinesia (GEPD). Epilepsy is one of the most common and debilitating neurological disorders. Paroxysmal dyskinesias are neurological disorders characterized by sudden, unpredictable, disabling attacks of involuntary movement often requiring life-long treatment. The coexistence of epilepsy and paroxysmal dyskinesia in the same individual or family is an increasingly recognized phenomenon. Patients manifest absence seizures, generalized tonic-clonic seizures, paroxysmal nonkinesigenic dyskinesia, involuntary dystonic or choreiform movements. Onset is usually in childhood and patients may have seizures only, dyskinesia only, or both.; Enzyme regulation: Ethanol and carbon monoxide-bound heme increase channel activation. Heme inhibits channel activation.; Subcellular location: Membrane, Multi-pass membrane protein.; Tissue specificity: Widely expressed. Except in myocytes, it is almost ubiquitously expressed.


Entrez Human
Uniprot Human
Product By Gene ID 3778
Alternate Names
  • BKCA alpha
  • Slo1
  • Slo-alpha
  • MGC71881
  • K(VCA)alpha
  • DKFZp686K1437
  • stretch-activated Kca channel
  • BKTM
  • k(VCA)alpha
  • hSlo
  • calcium-activated potassium channel subunit alpha-1
  • BK channel
  • BKCA alpha subunit
  • MaxiK
  • bA205K10.1
  • Slowpoke homolog
  • SLO1
  • Slo homolog
  • Maxi K channel
  • subfamily M subunit alpha-1
  • potassium large conductance calcium-activated channel, subfamily M, alphamember 1

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Potassium Channels

PTMs for Maxi Potassium channel alpha

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