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Microtubule-associated serine/threonine-protein kinase 4 or MAST4 is involved with protein phosphorylation and can be found within the cytoplasm. Belonging to the AGC Ser/Thr protein kinase family, MAST4 are cytoskeletal kinases associated with protein serine/threonine kinase activity; magnesium ion binding and ATP binding. Popular protein domains for MAST3 include PDZ, protein kinase, AGC-kinase C-terminal domain and domain of unknown function (DUF1908). MAST4 is also known to interact with SMAD1 and MYC. Diseases connected to MAST4 consist of Down syndrome and cystic lymphangioma.
