Species: Hu, Mu, Rt
Applications: WB, ELISA, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: AC
Description
Several mammalian kinases have been identified which exhibit sequence similarity to the Saccharomyces cerevisiae serine/threonine kinase STE20. STE20 is involved in relaying signals from G-protein coupled receptors to cytosolic MAP kinase cascades, and it lies upstream of a MAP kinase kinase kinase. Mammalian STE20-like kinases include GLK, KHS, NIK, YSK1, HPK1, Krs-1, Krs-2 and human GC kinase. GLK (for GC-like kinase) is an 885 amino acid protein that shares a high degree of homology with GC kinase and HPK1. Like many of the STE20-like kinases, GLK specifically activates the JNK pathway. Epistasis studies with dominant negative mutants of MEKK1 suggest that GLK functions upstream of MEKK1 in the JNK signaling pathway.
Bioinformatics
| Entrez |
Rat
Mouse
Human
|
| Uniprot |
Human
|
| Product By Gene ID |
8491 |
| Alternate Names |
- EC 2.7.11
- EC 2.7.11.1
- germinal center kinase-like kinase
- Germinal center kinase-related protein kinase
- GLKMEKKK 3
- MAPK/ERK kinase kinase kinase 3
- MAPKKKK3
- MEK kinase kinase 3
- mitogen-activated protein kinase kinase kinase kinase 3
- RAB8IPL1
|
