MAEL Products

Description

The mammalian homolog of the Drosophila protein Maelstrom is expressed in the male germline and localizes to the sex body in spermatocytes and the chromatoid body in round spermatids. Similar to its expression in Drosophila, Maelstrom is a component of nuages, a germ-cell specific organelle and is thought to be essential for spermatogenesis and transposon repression during meiosis. In humans, Maelstrom has been found to be expressed only in the testis and in various cancer cell lines. Treatment of these cell lines with the demethylating agent 5'-Aza-2-Deoxycytidine significantly upregulated Maelstrom levels, indicating that its expression is regulated by DNA methylation.

Bioinformatics

Uniprot	AAY82463 Human
Product By Gene ID	84944
Alternate Names	cancer/testis antigen 128 CT128 FLJ14904 maelstrom homolog (Drosophila) protein maelstrom homolog RP11-102C16.1

Research Areas for MAEL

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cell Cycle and Replication