Species: Hu, Rt
Applications: WB, ELISA, ICC/IF
Host: Mouse Monoclonal
Species: Hu, Mu, Rt, Ca
Applications: ELISA, Flow, ICC/IF
Host: Goat Polyclonal
Species: Hu, Rt
Applications: WB, ELISA
Host: Mouse Monoclonal
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
LXR-B belongs to the Liver X Receptor family that encodes highly homologous transcription factors. Like the highly homologous LXR-A, LXR-B forms heterodimers with the retinoic acid receptor RXRalpha, which function as sensors for cellular oxysterols which when activated, increase the expression of genes that control sterol and fatty acid metabolism and homeostasis. Recent experiments have indicated that the LXRs can also modulate both innate and adaptive immune responses. Other studies suggest that genetic variability at the LXR-B gene locus may be a risk factor for Alzheimer's disease. One hypothesis postulates that LXR may be upstream of ApoE and potentiates the risk associated effects of the epsilon3 allele.
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
|
| Product By Gene ID |
7376 |
| Alternate Names |
- Liver X receptor beta
- LXR beta
- LXR-b
- NER-I
- NERliver X receptor-beta
- NR1H2
- nuclear orphan receptor LXR-beta
- Nuclear receptor NER
- Nuclear receptor subfamily 1 group H member 2
- nuclear receptor subfamily 1, group H, member 2
- oxysterols receptor LXR-beta
- RIP15
- steroid hormone-nuclear receptor NER
- Ubiquitously-expressed nuclear receptorLXRB
- UNR
- UNRLX receptor beta
|
