LMBR1 Products

Description

This gene encodes a member of the LMBR1-like membrane protein family. Another member of this protein family has been shown to be a lipocalin transmembrane receptor. A highly conserved, cis-acting regulatory module for the sonic hedgehog gene is located within an intron of this gene. Consequently, disruption of this genic region can alter sonic hedgehog expression and affect limb patterning, but it is not known if this gene functions directly in limb development. Mutations and chromosomal deletions and rearrangements in this genic region are associated with acheiropody and preaxial polydactyly, which likely result from altered sonic hedgehog expression. [provided by RefSeq]

Bioinformatics

Product By Gene ID	64327
Alternate Names	ACHP ACHPchromosome 7 open reading frame 2 C7orf2 C7orf2FLJ11665 DIF14 Differentiation-related gene 14 protein limb region 1 homolog (mouse) limb region 1 protein homolog LMBR1 PPD2 THYP TPT ZRS