LLGL2 Products

Description

The lethal (2) giant larvae protein of Drosophila plays a role in asymmetric cell division, epithelial cell polarity, and cell migration. This human gene encodes a protein similar to lethal (2) giant larvae of Drosophila. In fly, the protein's ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells. Alternative splicing results in multiple transcript variants encoding different isoforms.

Bioinformatics

Entrez	3993 Human 217325 Mouse
Uniprot	Q6P1M3 Human AAH64994.1 Human NP_004515 Human
Product By Gene ID	3993
Alternate Names	lethal(2) giant larvae protein homolog 2 human giant larvae homolog LGL2 HGLlethal giant larvae (Drosophila) homolog 2 lethal giant larvae homolog 2 (Drosophila)

Diseases related to LLGL2

Discover more about diseases related to LLGL2.

Neoplasms
Ischemic Stroke
Brain Ischemia
Cerebrovascular Accident
Cell Invasion
Cell Transformation, Neoplastic
Tumor Progression
Severe Congenital Neutropenia
Leukemia, Myelocytic, Acute
Carcinoid Tumor
Myeloid Leukemia
Leukemia
Germ Cell Tumor
Dysequilibrium Syndrome

Pathways for LLGL2

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Pathogenesis

Bioinformatics Tool for LLGL2

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