LAMC2 Products

LAMC2 Antibody (CL2980)
LAMC2 Antibody (CL2980)
Species: Hu
Applications: WB, IHC, IHC-P
Host: Mouse Monoclonal
LAMC2 Antibody
LAMC2 Antibody
Species: Hu
Applications: IHC, IHC-P
Host: Rabbit Polyclonal
LAMC2 Overexpression Lysate ( ...
LAMC2 Overexpression Lysate (Native)
Applications: WB
LAMC2 Overexpression Lysate ( ...
LAMC2 Overexpression Lysate (Native)
Applications: WB
LAMC2 Overexpression Lysate ( ...
LAMC2 Overexpression Lysate (Native)
Applications: WB
LAMC2 Partial Recombinant Pro ...
LAMC2 Partial Recombinant Protein
Species: Hu
Applications: WB, ELISA, PA
LAMC2 Recombinant Protein Ant ...
LAMC2 Recombinant Protein Antigen
Species: Hu
Applications: B/N, Ctrl


Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 2. The gamma 2 chain, formerly thought to be a truncated version of beta chain (B2t), is highly homologous to the gamma 1 chain; however, it lacks domain VI, and domains V, IV and III are shorter. It is expressed in several fetal tissues but differently from gamma 1, and is specifically localized to epithelial cells in skin, lung and kidney. The gamma 2 chain together with alpha 3 and beta 3 chains constitute laminin 5 (earlier known as kalinin), which is an integral part of the anchoring filaments that connect epithelial cells to the underlying basement membrane. The epithelium-specific expression of the gamma 2 chain implied its role as an epithelium attachment molecule, and mutations in this gene have been associated with junctional epidermolysis bullosa, a skin disease characterized by blisters due to disruption of the epidermal-dermal junction. Two transcript variants resulting from alternative splicing of the 3' terminal exon, and encoding different isoforms of gamma 2 chain, have been described. The two variants are differentially expressed in embryonic tissues, however, the biological significance of the two forms is not known. Transcript variants utilizing alternative polyA_signal have also been noted in literature.


Entrez Human
Uniprot Human
Product By Gene ID 3918
Alternate Names
  • Kalinin/nicein/epiligrin 100 kDa subunit
  • Nicein subunit gamma
  • nicein (100kDa)
  • Large adhesive scatter factor 140 kDa subunit
  • laminin subunit gamma-2
  • Laminin-5 subunit gamma
  • ladsin (140kDa)
  • Laminin B2t chain
  • kalinin (105kD)
  • Ladsin 140 kDa subunit
  • MGC141938
  • Kalinin subunit gamma
  • MGC138491
  • Epiligrin subunit gamma
  • EBR2A
  • Cell-scattering factor 140 kDa subunit
  • EBR2
  • nicein-100kDa
  • CSF
  • kalinin-105kDa
  • BM600
  • BM600-100kDa
  • LAMB2Tlaminin, gamma 2 (nicein (100kD), kalinin (105kD), BM600 (100kD), Herlitzjunctional epidermolysis bullosa))
  • CSF 140 kDa subunit
  • laminin, gamma 2

PTMs for LAMC2

Learn more about PTMs related to LAMC2.


Bioinformatics Tool for LAMC2

Discover related pathways, diseases and genes to LAMC2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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