Kv1.4 Products

Description

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the A-type potassium current class, the members of which may be important in the regulation of the fast repolarizing phase of action potentials in heart and thus may influnce the duration of cardiac action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1.

Bioinformatics

Entrez	3739 Human
Uniprot	NP_002224 Human
Product By Gene ID	3739
Alternate Names	cardiac potassium channel fetal skeletal muscle potassium channel HBK4 HK1 HPCN2 HPCN2HUKII KCNA4 KCNA4L KCNA8 Kv1.4 PCN2 potassium channel 2 potassium voltage-gated channel subfamily A member 4 potassium voltage-gated channel, shaker-related subfamily, member 4 potassium voltage-gated channel, shaker-related subfamily, member 4-like rapidly inactivating potassium channel shaker-related potassium channel Kv1.4 type A potassium channel Voltage-gated K(+) channel HuKII Voltage-gated potassium channel HBK4 Voltage-gated potassium channel HK1 Voltage-gated potassium channel subunit Kv1.4

Research Areas for Kv1.4

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Neuroscience