Kos1/Tnk1 Products

Antibodies
Kos1/Tnk1 Antibody
Kos1/Tnk1 Antibody
NB300-237
Species: Hu, Mu
Applications: WB, ICC/IF
Host: Rabbit Polyclonal

Description

Kinase of embryonic stem cells (Kos1) is a nonreceptor protein tyrosine kinase (NRPTK) and a new member of the Ack family of NRPTKs. Kos1 is a ubiquitously expressed 47-kDa protein with autotyrosine kinase activity that is developmentally regulated during embryogenesis. Kos1 is also upregulated following IL3 withdrawal from factor-dependent murine NSF/N1.H7 cells that undergo apoptosis, suggesting a role in growth inhibition. Data support a negative regulatory role for Kos1 in regulating the Ras-Raf1-MAPK growth pathway by a mechanism that requires its autotyrosine kinase activity.

Bioinformatics

Entrez Mouse
Uniprot Mouse