Kindlin Products

Description

Due to a concerted effort to identify biomarkers for lung and colon carcinomas by genome-wide transcriptional profiling, the identification and cloning of one such gene as well as two additional closely related genes was achieved. Due to the strong sequence homology to the C. elegans UNC-112 a novel gene gene was named URP1, for UNC-112 related protein. Another novel related gene, URP2 and the previously discovered MIG-2 gene was also identified. Transcriptional analysis shows that only URP1 is significantly differentially regulated, being over-expressed in 70% of the colon carcinomas and 60% of the lung carcinomas tested. Quantification of URP1 expression by qRT-PCR showed up-regulation of the gene by 60-fold in lung tumors and up to nearly 6-fold in colon tumors. Northern blot analysis of URP1 indicates that normal expression is restricted to neuromuscular tissues. In contrast, the expression of URP2 appears to be confined primarily to tissues of the immune system. URP1 has the potential to be one of the most important prognostic and diagnostic markers of colon or lung cancer.

Bioinformatics

Entrez	55612 Human
Uniprot	NP_060141 Human Q9BQL6 Human
Product By Gene ID	55612
Alternate Names	C20orf42fermitin family homolog 1 chromosome 20 open reading frame 42 fermitin family homolog 1 (Drosophila) fermitin family member 1 FLJ20116 KIND1DTGCU2 Kindlerin kindlerin kindlin 1 Kindlin syndrome protein Kindlin-1 UNC112 related protein 1 UNC112A Unc-112-related protein 1 URP1FLJ23423

Diseases related to Kindlin

Discover more about diseases related to Kindlin.

Poikiloderma Of Kindler
Bulla
Tissue Adhesions
Photosensitivity Disorders
Skin Diseases, Genetic
Epidermolysis Bullosa
Periodontal Diseases
Malignant Neoplasms
Atrophy
Neoplasms
Atrophic Condition Of Skin
Rothmund-thomson Syndrome
Dermatologic Disorders
Carcinoma
Cell Invasion
Malignant Neoplasm Of Skin
Inflammation
Colitis

Pathways for Kindlin

View related products by pathway and learn more about each of the pathways below.

Integrin Activation
Cell Adhesion
Pigmentation
Localization
Cell Proliferation
Cell Growth
Pathogenesis
Cell Migration
Cell-matrix Adhesion
Inflammatory Response
Cell Motility
Actin Cytoskeleton Organization
Cytokine Secretion
Keratinocyte Migration
Cytoskeleton Organization
Reverse Transcription
Translation
Keratinocyte Proliferation
Wound Healing
Mitotic Recombination

PTMs for Kindlin

Learn more about PTMs related to Kindlin.

Phosphorylation

Bioinformatics Tool for Kindlin

Discover related pathways, diseases and genes to Kindlin. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.