JNK3 Products

Description

MAPK10 (JNK3) is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuron-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways of neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 (CDK5) can phosphorylate and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

Bioinformatics

Entrez	25272 Rat 26414 Mouse 5602 Human
Uniprot	AAH65516 Human AAH65516.1 Human NM_138980 Human NM_138981 Human NM_138982 Human P53779 Human
Product By Gene ID	5602
Alternate Names	c-Jun N-terminal kinase 3 EC 2.7.11 EC 2.7.11.24 JNK3 alpha protein kinase JNK3A JNK3FLJ12099 MAP kinase 10 MAP kinase p49 3F12 MAPK 10 MGC50974 mitogen-activated protein kinase 10 p493F12 p54bSAPK PRKM10FLJ33785 stress activated protein kinase beta Stress-activated protein kinase JNK3

Research Areas for JNK3

Find related products by research area and learn more about each of the different research areas below.

Immunology
Innate Immunity
Protein Kinase
Wnt Signaling Pathway