Jak2 Products

Antibodies
Jak2 Antibody (53B7)
Jak2 Antibody (53B7)
NBP2-59451
Species: Hu
Applications: WB, ELISA, Flow, ICC/IF
Host: Mouse Monoclonal
Conjugate Catalog # Availability Size Price
Jak2 [p Tyr1007, p Tyr1008] A ...
Jak2 [p Tyr1007, p Tyr1008] Antibo...
NBP2-67429
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P, IP
Host: Rabbit Monoclonal
Jak2 Antibody (6-D3)
Jak2 Antibody (6-D3)
NBP2-66913
Species: Hu, Mu, Rt
Applications: WB, Flow, ICC/IF, IHC, IHC-P
Host: Mouse Monoclonal
Proteins
Recombinant Human Jak2 Protei ...
Recombinant Human Jak2 Protein
NBP2-23154
Species: Hu
Applications: PAGE
Jak2 Recombinant Protein Anti ...
Jak2 Recombinant Protein Antigen
NBP2-38476PEP
Species: Hu
Applications: AC
Jak2 Recombinant Protein Anti ...
Jak2 Recombinant Protein Antigen
NBP2-55362PEP
Species: Hu
Applications: AC

Description

Jak2 is a member of the Janus family tyrosine kinases (Jaks), whose function is to transduce extracellular signals from cytokines and interferons. Jaks associate with cytokine receptors; upon ligand binding, Jaks phosphorylate the receptor. The phosphorylated receptors are bound by SH2-containing proteins, one class of which is the signal transducers and activators of transcription (STATs). Activated STATs, then, translocate to the nucleus to mediate gene transcription (1,2). Tyr1007/1008 of Jak2 are the homologous Tyr1054/1055 in Tyk2, and phosphorylation at these residues is needed for Tyk2 activation (3). A chromosomal aberration involving Jak2 is found in a form of pre-B acute myeloid leukemia (4).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Product By Gene ID 3717
Alternate Names
  • EC 2.7.10.2
  • EC 2.7.10
  • JAK-2
  • tyrosine-protein kinase JAK2
  • JTK10
  • Janus kinase 2Janus kinase 2 (a protein tyrosine kinase)

Research Areas for Jak2

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication
Phospho-Specific
Signal Transduction

Bioinformatics Tool for Jak2

Discover related pathways, diseases and genes to Jak2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related Jak2 Blog Posts

Check out the latest blog posts on Jak2.
Signal Transducer and Activator of Transcription STAT6: More than a Player in Allergic Inflammation
By Jamshed Arslan, Pharm. D., PhD. What is STAT6?The cellular pathway comprising tyrosine kinase Janus Kinase (JAK) and the transcription factor STAT connect extracellular signals from various cytokines, hormones an...    Read more.
Using a STAT3 antibody in chromatin immunoprecipitation (ChIP)
Signal transducer and activator of transcription 3 (STAT3) is an important oncogenic transcriptional factor that mediates tumor induced immune suppression.  Specifically, STAT3 transmits signals from cytokines and growth factor receptors in the pla...    Read more.
Read more Jak2 related blogs.