IRS4 Products

Antibodies
IRS4 Antibody
IRS4 Antibody
NBP2-14130
Species: Hu
Applications: IHC, IHC-P
Host: Rabbit Polyclonal
IRS4 Antibody (5B9)
IRS4 Antibody (5B9)
H00008471-M01
Species: Hu
Applications: WB, ELISA
Host: Mouse Monoclonal
Lysates
IRS4 Overexpression Lysate (N ...
IRS4 Overexpression Lysate (Native)
NBL1-12040
Applications: WB
Proteins
IRS4 Partial Recombinant Prot ...
IRS4 Partial Recombinant Protein
H00008471-Q01
Species: Hu
Applications: WB, ELISA, PA
IRS4 Recombinant Protein Anti ...
IRS4 Recombinant Protein Antigen
NBP2-14130PEP
Species: Hu
Applications: AC
RNAi
IRS4 RNAi
IRS4 RNAi
H00008471-R02
Species: Hu
Applications: RNAi, RNAi SP

Description

IRS4 is a new member of the IRS family, IRS-4, is a 160-kDa tyrosine kinase which phosphorylates cellular substrates when it is activated by the binding of insulin (1). IRS-4 was originally discovered in human embryonic kidney 293 cells. Subcellular fractionation revealed that about 50% of IRS-4 was located in cellular membranes, and immunofluorescence indicated that IRS-4 was concentrated at the plasma membrane. Immunoelectron microscopy conclusively established that a large portion of the IRS-4 was located at the cytoplasmic surface of the plasma membrane in both the unstimulated and insulin-treated states. IRS-4 was found to be associated with two src homology 2 (SH2) domain-containing proteins, phosphatidylinositol 3-kinase and Grb2, the adaptor to the guanine nucleotide exchange factor for Ras (2).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Product By Gene ID 8471
Alternate Names
  • Phosphoprotein of 160 kDa
  • py160
  • PY160
  • IRS-4pp160
  • insulin receptor substrate 4,160 kDa phosphotyrosine protein

PTMs for IRS4

Learn more about PTMs related to IRS4.

Phosphorylation
Ubiquitination
Cleavage

Bioinformatics Tool for IRS4

Discover related pathways, diseases and genes to IRS4. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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