INF2 Products

Antibodies
INF2 Antibody
INF2 Antibody
NBP1-88414
Species: Hu, Mouse, Rat
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
INF2 Antibody
INF2 Antibody
NBP1-79026
Species: Hu, Primate, Rat, Chinese Hamster, Monkey
Applications: WB, IP
Host: Rabbit Polyclonal
INF2 Antibody
INF2 Antibody
NBP1-79025
Species: Hu, Bovine, Canine, Equine, Guinea Pig, Primate, Mouse, Rat, Monkey
Applications: WB, IP
Host: Rabbit Polyclonal
Lysates
INF2 Overexpression Lysate (N ...
INF2 Overexpression Lysate (Native)
NBL1-08180
Applications: WB
INF2 Overexpression Lysate (D ...
INF2 Overexpression Lysate (Denatu...
H00064423-T03
Species: Hu
Applications: WB
Proteins
INF2 Recombinant Protein
INF2 Recombinant Protein
H00064423-P01
Species: Hu
Applications: WB, ELISA, PA
INF2 Recombinant Protein Anti ...
INF2 Recombinant Protein Antigen
NBP1-88414PEP
Species: Hu
Applications: AC
INF2 Recombinant Protein
INF2 Recombinant Protein
H00064423-P02
Species: Hu
Applications: WB, ELISA, PA

Description

Actin filaments grow only when actin monomers have access to the fast-growing barbed end of the filament. The geometry of the filament network depends on the actions of the ARP2/3 complex (MIM 604221) and members of the formin family, such as INF2. The ARP2/3 complex binds to the sides of preexisting filaments and nucleates filaments whose barbed ends are quickly blocked by capping proteins, producing brush-like structures, such as those found at the leading edges of crawling cells. In contrast, formins bind to the barbed ends of growing filaments and protect them from capping, creating long filaments that can be cross-linked into bundles, such as those found in actin cables of yeast. Interaction of formins with actin barbed ends occurs through the formin homology-2 (FH2) domain. FH2 domains accelerate filament nucleation, move with the barbed end as the filament grows, and block capping of the barbed end by proteins such as gelsolin (GSN; MIM 137350). The FH1 domain of formins binds to profilin (see MIM 176610) and accelerates elongation from the FH2-bound barbed ends (Bindschadler and McGrath, 2004 [PubMed 15466701]; Chhabra and Higgs, 2006 [PubMed 16818491]).[supplied by OMIM]

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Product By Gene ID 64423
Alternate Names
  • pp9484
  • chromosome 14 open reading frame 151
  • inverted formin-2
  • FSGS5
  • HBEAG-binding protein 2 binding protein C
  • HBEBP2-binding protein C
  • C14orf151
  • FLJ22056
  • MGC13251
  • C14orf173DKFZp762A0214
  • chromosome 14 open reading frame 173
  • inverted formin, FH2 and WH2 domain containing

PTMs for INF2

Learn more about PTMs related to INF2.

Oxidation
Nitration
Reduction
Cleavage
Demethylation
Phosphorylation

Bioinformatics Tool for INF2

Discover related pathways, diseases and genes to INF2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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