IL-5R alpha/CD125 Products

Description

The protein encoded by the IL5RA gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Six alternatively spliced transcript variants encoding three distinct isoforms have been reported. (provided by RefSeq)

Bioinformatics

Entrez	3568 Human
Uniprot	NM_000564 Human NM_175724 Human NM_175725 Human NM_175726 Human NM_175727 Human NM_175728 Human NP_783852.1 Human Q01344 Human
Product By Gene ID	3568
Alternate Names	CD125 antigen CDw125CD125 HSIL5R3 IL-5 receptor subunit alpha IL-5R subunit alpha IL5R IL-5RA IL-5R-alpha interleukin 5 receptor type 3 interleukin 5 receptor, alpha interleukin-5 receptor alpha chain interleukin-5 receptor alpha subunit interleukin-5 receptor subunit alpha MGC26560