IFN-alpha G/IFNA5 Products

Description

Interferons (IFN) are a family of cytokines with potent antiviral, antiproliferative and immunomodulatory properties, classified based on their binding specificity to cell surface receptors (1). Human IFNA2 was originally cloned in the early ‘80s and now more than a dozen closely related IFN alpha subtypes have been identified in both the human and mouse genome, each sharing about 80% amino acid (aa) sequence homology (2-4). Structurally, type I IFNs belong to the class of five helical‑bundle cytokines, with the IFNA subtypes containing 2 conserved disulfide bonds (5). The mature human IFNA5, also known as IFN-alpha G, shares 40% aa sequence identity with mouse IFNA5. The type I IFNs bind to the interferon alpha receptor (IFNAR), which consists of two subunits: IFNAR1 (alpha -subunit) and IFNAR2 (beta -subunit) (6, 7). Individual IFNA subtypes are known to display unique efficacies to viral protection, and IFNA5 has been shown to be an intermediate inducer of IFN‑stimulated genes and anti-viral protection (8). IFNA5 is the only IFNA subtype detected in normal liver and has been shown to induce stronger signaling and higher expression of antiviral genes than IFNA2 in hepatocytic cells (9). IFNA5 also exhibits strong antiviral effects against SARS‑CoV‑2 (10).

Bioinformatics

Uniprot	P01569.1
Product By Gene ID	3442
Alternate Names	Ifa5 IFNA5 IFNalpha G IFN-alpha G IFN-alpha-5 IFN-alphaG INFA5 interferon alpha-5 Interferon alpha-61 Interferon alpha-G interferon, alpha 5 LeIF G