IFN-alpha 9 Products

Description

Interferons (IFN) are a family of cytokines with potent antiviral, antiproliferative and immunomodulatory properties, classified based on their binding specificity to cell surface receptors (1). There are more than a dozen closely related IFN alpha subtypes found in both the human and mouse genome, each sharing about 80% amino acid (aa) sequence homology (2, 3). The extracellular domain (ECD) of mature mouse IFNA9 consists of 166 amino acids (aa), with the closest homolog identified in humans as IFNA1. The type I IFNs bind to the interferon alpha receptor (IFNAR), which consists of two subunits: IFNAR1 (alpha -subunit) and IFNAR2 (beta -subunit) (4, 5). Individual IFN alpha subtypes are known to display unique efficacies to viral protection. In gB DNA-Vaccinated mice, coimmunisation with IFNA9 has been shown to enhance protective immunity against cytomegalovirus and myocarditis (5).

Bioinformatics

Uniprot	P09235.1
Product By Gene ID	15972
Alternate Names	IFA9 IFNA9 IFN-alpha 9