iASPP Products

Description

ASPP proteins (ASPP1, ASPP2 and iASPP) represent a new family of p53 binding proteins. ASPP1 and ASPP2 bind and enhance p53-mediated apoptosis. In contrast, the third member, iASPP, functionally inactivates p53. iASPP (also called protein phosphatase 1 regulatory (inhibitor) subunit 13 like protein, Inhibitor of ASPP protein, Protein iASPP, PPP1R13B-like protein and NFkB-interacting protein 1) plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. iASPP blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. This protein also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis. iASPP is predominantly a cytoplasmic protein (isoform 1) but can also be found in the nucleus (isoform 2). iASPP is highly expressed in heart, placenta and prostate and is weakly expressed in brain, liver, skeletal muscle, testis and peripheral blood leukocyte. The N-terminal region of isoform 1 is required for cytoplasmic localization. Defects in iASPP may be a cause of certain breast cancers and the protein is overexpressed in many patients suffering from breast carcinomas and expressing a wild-type p53/TP53 protein.

Bioinformatics

Entrez	10848 Human
Uniprot	AAH64913 Human AAH64913.1 Human NP_006654 Human NP_006654.2 Human Q8WUF5 Human
Product By Gene ID	10848
Alternate Names	IASPPinhibitor of apoptosis stimulating protein of p53 Inhibitor of ASPP protein NFkB-interacting protein 1 NKIP1 PPP1R13BL PPP1R13B-like protein Protein iASPP protein phosphatase 1, regulatory (inhibitor) subunit 13 like protein phosphatase 1, regulatory subunit 13 like RAINFkB interacting protein 1 relA-associated inhibitor

Diseases related to iASPP

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Malignant Neoplasms
Neoplasms
Carcinoma
Malignant Neoplasm Of Lung
Lung Neoplasms
Malignant Neoplasm Of Breast
Cell Transformation, Neoplastic
Mammary Neoplasms
Adenocarcinoma
Non-small Cell Lung Carcinoma
Multiple Myeloma
Dysequilibrium Syndrome
Liver Carcinoma
Acute Leukemia
Basal Cell Carcinoma
Colorectal Cancer
Colorectal Neoplasms
Liver Neoplasms
Leukemia

Pathways for iASPP

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Cell Proliferation
Dna Repair
Cell Cycle
Pathogenesis
Rna Interference
Cell Cycle Arrest
Translation
Cell Death
Transport
Cell Adhesion
Cellular Senescence
Skin Development
Localization
Epithelial To Mesenchymal Transition
Senescence
Mitotic Catastrophe
Cell Growth
Eye Development
Homeostatic Process
Glucose Transport

Research Areas for iASPP

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Apoptosis
Cancer
Caspases

PTMs for iASPP

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Phosphorylation
Acetylation

Bioinformatics Tool for iASPP

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