iASPP Products

Antibodies
iASPP Antibody
iASPP Antibody
NBP2-48732
Species: Hu
Applications: ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
iASPP Antibody
iASPP Antibody
NBP1-77912
Species: Hu
Applications: WB, ELISA, IHC, IHC-P
Host: Rabbit Polyclonal
iASPP Antibody
iASPP Antibody
H00010848-B01P
Species: Hu
Applications: WB, ELISA, ICC/IF
Host: Mouse Polyclonal
Lysates
iASPP Overexpression Lysate ( ...
iASPP Overexpression Lysate (Denat...
H00010848-T01
Species: Hu
Applications: WB
Proteins
iASPP Recombinant Protein
iASPP Recombinant Protein
H00010848-P01
Species: Hu
Applications: WB, ELISA, PA
iASPP Partial Recombinant Pro ...
iASPP Partial Recombinant Protein
H00010848-Q01
Species: Hu
Applications: WB, ELISA, PA
iASPP Recombinant Protein Ant ...
iASPP Recombinant Protein Antigen
NBP2-38879PEP
Species: Hu
Applications: AC
RNAi
iASPP RNAi
iASPP RNAi
H00010848-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

ASPP proteins (ASPP1, ASPP2 and iASPP) represent a new family of p53 binding proteins. ASPP1 and ASPP2 bind and enhance p53-mediated apoptosis. In contrast, the third member, iASPP, functionally inactivates p53. iASPP (also called protein phosphatase 1 regulatory (inhibitor) subunit 13 like protein, Inhibitor of ASPP protein, Protein iASPP, PPP1R13B-like protein and NFkB-interacting protein 1) plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. iASPP blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. This protein also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis. iASPP is predominantly a cytoplasmic protein (isoform 1) but can also be found in the nucleus (isoform 2). iASPP is highly expressed in heart, placenta and prostate and is weakly expressed in brain, liver, skeletal muscle, testis and peripheral blood leukocyte. The N-terminal region of isoform 1 is required for cytoplasmic localization. Defects in iASPP may be a cause of certain breast cancers and the protein is overexpressed in many patients suffering from breast carcinomas and expressing a wild-type p53/TP53 protein.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 10848
Alternate Names
  • NFkB-interacting protein 1
  • PPP1R13BL
  • NKIP1
  • relA-associated inhibitor
  • Protein iASPP
  • protein phosphatase 1, regulatory subunit 13 like
  • Inhibitor of ASPP protein
  • RAINFkB interacting protein 1
  • IASPPinhibitor of apoptosis stimulating protein of p53
  • PPP1R13B-like protein
  • protein phosphatase 1, regulatory (inhibitor) subunit 13 like

Research Areas for iASPP

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Caspases

PTMs for iASPP

Learn more about PTMs related to iASPP.

Phosphorylation
Acetylation

Bioinformatics Tool for iASPP

Discover related pathways, diseases and genes to iASPP. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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