HSF1 Products

Antibodies
HSF1 Antibody
HSF1 Antibody
NBP1-97475
Species: Hu, Mu, Rt, Ge, Pm, Rb
Applications: WB, EIA, ELISA, GS, IP
Host: Rabbit Polyclonal
HSF1 Antibody
HSF1 Antibody
NB300-730
Species: Hu, Mu, Rt
Applications: WB, ELISA, GS, ICC/IF, IP
Host: Rabbit Polyclonal
HSF1 Antibody
HSF1 Antibody
NBP1-81665
Species: Hu, Mouse, Rat
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
HSF1 Overexpression Lysate (N ...
HSF1 Overexpression Lysate (Native)
NBP2-07736
Applications: WB
Proteins
HSF1 Recombinant Protein
HSF1 Recombinant Protein
NBC1-18373
Species: Hu
Applications: PAGE
HSF1 Recombinant Protein Anti ...
HSF1 Recombinant Protein Antigen
NBP1-81665PEP
Species: Hu
Applications: AC
RNAi
HSF1 RNAi
HSF1 RNAi
H00003297-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

Human cells respond to heat stress by inducing the binding of a pre-existing transcriptional activator (heat shock factor, HSF) to DNA (1). Induction of heat shock protein (HSP) gene expression by stress is initiated by binding of HSF1 to HSP gene promoters to increase their transcription. The cytoprotective functions of these HSPs are essential for cell survival, and thus it is critical that inducible HSP gene expression be executed rapidly and efficiently. There is an interaction between heat shock factor 1 (HSF1) and symplekin, a protein known to form a complex with the polyadenylation factors CstF and CPSF. HSF1-symplekin complexes are detected only after stress treatment, and these two proteins co-localize in punctate nuclear structures in stressed cells (2). A chaperone/Hsp functioning as repressor of heat shock transcription factor (HSF) could make activation of hsp genes dependent on protein unfolding. It has been concluded that Hsp90, by itself and/or associated with multichaperone complexes, is a major repressor of HSF1 (3).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Product By Gene ID 3297
Alternate Names
  • heat shock factor protein 1
  • HSTF 1
  • heat shock transcription factor 1HSTF1HSF 1

Research Areas for HSF1

Find related products by research area and learn more about each of the different research areas below.

Cancer
DNA Repair
Phospho-Specific
Transcription Factors and Regulators

Bioinformatics Tool for HSF1

Discover related pathways, diseases and genes to HSF1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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