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One of the many clones sequenced and characterized coded a 167 amino acids long protein names Chromosome 3 Open reading frame 34 or HSD5. HSD5 is a soluble protein with at least one functional motif based on sequence homology. There exists a phosphoenol pyruvate carboxylase (Ppc) domain starting near the N-terminal domain. The presence of Ppc domain in HSD5 suggest that this gene may be involved in energy production and conversion pathways. Recent data from gene array analyses and differential expression studies suggest that this gene is expressed in various splice variant form and is up-regulated in various cancer cells including prostate and breast cancer cell lines.
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