HSBP1 Products

Description

The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation ofHSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor bindingprotein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factorinvolved in the HS response. During HS response, HSF1 undergoes conformational transition from an inertnon-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the activetrimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cellsrepresses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survivalof the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shockresponse. (provided by RefSeq)

Bioinformatics

Entrez	3281 Human
Uniprot	AAH07515 Human NP_001528.1 Human O75506 Human
Product By Gene ID	3281
Alternate Names	DKFZp686D1664 DKFZp686O24200 heat shock factor binding protein 1 heat shock factor-binding protein 1 HSF1BP Nasopharyngeal carcinoma-associated antigen 13 NPC-A-13