HR6A/UBE2A Products

Description

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins. Involved in placental, cardiac, hepatic and embryonic development. NCOA6 is over-expressed in several breast cancer cell lines.

Bioinformatics

Entrez	7319 Human
Uniprot	NP_003327 Human AAH10175 Human P49459 Human NM_003336 Human
Product By Gene ID	7319
Alternate Names	Ubiquitin-protein ligase A hHR6A Ubiquitin carrier protein A ubiquitin-conjugating enzyme E2 A UBC2 EC 6.3.2.19 HHR6A RAD6ARAD6 homolog A HR6A ubiquitin-conjugating enzyme E2A (RAD6 homolog)

Diseases related to HR6A/UBE2A

Discover more about diseases related to HR6A/UBE2A.

Malignant Neoplasms
Infertility
Neoplasms
Orbital Separation Excessive
Male Infertility
Neoplasm Metastasis
Malignant Neoplasm Of Breast
Inflammatory Bowel Diseases
Glaucoma, Open-angle
Knight's Move In Thought
Intestinal Diseases
Carcinoma
Ventricular Septal Defects
Recurrence (disease Attribute)

Pathways for HR6A/UBE2A

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Dna Repair
Sporulation
Spermatogenesis
Cell Cycle
Postreplication Repair
Conjugation
Methylation
Histone Modification
Prophase
Chromatin Modification
Meiosis
Localization
Dna Replication
Pachytene
Transport
Histone Ubiquitination
Proteolysis
Sex Determination
Embryo Development
Blastocyst Hatching

Research Areas for HR6A/UBE2A

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DNA Repair
Ubiquitin Proteasome Pathway

PTMs for HR6A/UBE2A

Learn more about PTMs related to HR6A/UBE2A.

Ubiquitination
Phosphorylation
Methylation
Sumoylation
Biotinylation
Cleavage

Bioinformatics Tool for HR6A/UBE2A

Discover related pathways, diseases and genes to HR6A/UBE2A. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.