HOXA1 Products

Description

Hox genes play a fundamental role in the development of the vertebrate central nervous system, heart, axial skeleton, limbs, gut, urogenital tract and external genitalia. The homeobox gene HOXA1 is transcriptionally regulated by retinoic acid (RA) and encodes a transcription factor which has been shown to play important roles in cell differentiation and embryogenesis. HoxA1 is also expressed in cancers, such as mammary tumors, though it is not expressed in normal gland or in precancerous mammary tissues. At embryonic stages, HoxA2 is expressed in the mesenchyme and epithelial cells of the palate, however its expression is restricted to the tips of the growing palatal shelves. HoxA2 protein is predominantly expressed in the nuclei of cells in the ventral mantle region of the developing embryo. In the developing and adult mouse spinal cord, HoxA2 protein may contribute to dorsal-ventral patterning and/or to the specification of neuronal phenotype. HoxA7 functions as a potent transcriptional repressor and its action as such requires several domains, including both activator and repressor regions. HoxA7 is expressed in the fetal liver, lung, skeletal muscle, kidney, pancreas and placenta.

Bioinformatics

Entrez	3198 Human 25607 Rat
Uniprot	P49639
Product By Gene ID	3198
Alternate Names	BSAS homeo box A1 homeobox A1 Homeobox protein Hox-1F homeobox protein Hox-A1 Hox 1.6-like protein HOX A1 homeodomain protein HOX1 HOX1F HOX1Fhomeobox 1F HOXA1 lab-like protein MGC45232