HMW Kininogen Products

Antibodies
HMW Kininogen Antibody
HMW Kininogen Antibody
NBP1-31340
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
HMW Kininogen Antibody
HMW Kininogen Antibody
H00003827-D01P
Species: Hu, Mu
Applications: WB, ELISA
Host: Rabbit Polyclonal
HMW Kininogen Antibody
HMW Kininogen Antibody
H00003827-B01P
Species: Hu
Applications: WB, ELISA
Host: Mouse Polyclonal
Antibody Pairs
HMW Kininogen Antibody Pair
HMW Kininogen Antibody Pair
H00003827-PW1
Species: Hu
Applications: WB, IP
Lysates
HMW Kininogen Overexpression ...
HMW Kininogen Overexpression Lysat...
H00003827-T01
Species: Hu
Applications: WB
HMW Kininogen Overexpression ...
HMW Kininogen Overexpression Lysat...
NBL1-12368
Applications: WB
Proteins
HMW Kininogen Recombinant Pro ...
HMW Kininogen Recombinant Protein
H00003827-P01
Species: Hu
Applications: WB, ELISA, PA
HMW Kininogen Partial Recombi ...
HMW Kininogen Partial Recombinant ...
H00003827-Q01
Species: Hu
Applications: WB, ELISA, PA
RNAi
HMW Kininogen RNAi
HMW Kininogen RNAi
H00003827-R01
Species: Hu

Description

High molecular weight kininogen (HMWK) plays an important role in assembly of the plasma kallikrein (see MIM 147910)-kinin system. The KNG1 gene generates both HMWK and low molecular weight kininogen (LMWK) through alternative splicing. Both HMWK and LMWK contain an identical heavy chain consisting of protein domains 1, 2, and 3. However, HMWK contains a 56-kD light chain that consists of domains 5 and 6H, whereas LMWK contains a unique 4-kD light chain that consists of domain 5L. In both proteins, the heavy and light chains are linked by domain 4, which contains the bradykinin (BK) nonapeptide. BK, which is released by plasma kallikrein, is a potent inflammatory mediator that causes vasodilation and enhanced capillary permeability, induces pain, and stimulates production of nitric oxide and prostacyclin (see MIM 601699) from endothelial cells. During vascular damage, BK stimulates smooth muscle proliferation and intimal hypertrophy. Release of BK from HMWK generates a 2-chain HMWK, termed HMWKa, containing the heavy and light chains joined by a disulfide bond (Merkulov et al., 2008 [PubMed 18000168]).[supplied by OMIM]

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Product By Gene ID 3827
Alternate Names
  • kininogen-1
  • Williams-Fitzgerald-Flaujeac factor
  • bradykinin
  • High molecular weight kininogen
  • Fitzgerald factor
  • kininogen
  • Alpha-2-thiol proteinase inhibitor
  • KNGHMWK
  • BDK
  • kininogen 1

Pathways for HMW Kininogen

View related products by pathway and learn more about each of the pathways below.

Coagulation
Glucose Homeostasis
Translation
Biological Regulation
Pathogenesis

Research Areas for HMW Kininogen

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Immunology

Bioinformatics Tool for HMW Kininogen

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