HMGN1/HMG14 Products

Description

HMGNs are proteins that bind chromatin effectively reducing the compaction of the chromatin fiber and enhancing access to DNA regulatory sequences. Members of this family have a conserved chromatin binding domain which is phosphorylated during mitosis. The sequence immunized is conserved in several species. As such, this reagent is designed as a universal reagent for the detection of all phosphorylated HMGN proteins. The High Mobility Group (HMG) proteins were originally isolated from mammalian cells and were named according to their electrophoretic mobility in polyacrylamide gels. HMGs were arbitrarily classed as a specific type of nonhistone proteins based on the observation that they are ubiquitous to mammalian cells, that they share certain physical properties, and that they are associated with isolated chromatin. HMG proteins and are now subdivided into 3 families: the HMGB (formerly HMG-1/-2) family, the HMGN (formerly HMG-14/-17) family, and the HMGA (formerly HMG-I/Y/C) family. Each HMG family has a characteristic functional sequence motif. The functional motif of the HMGB family is called the "HMG-box;" that of the HMGN family, the "nucleosomal binding domain;" and that of the HMGA family, the "AT-hook." The functional motifs characteristic of these canonical HMGs are widespread among nuclear proteins in a variety of organisms. Proteins containing any of these functional motifs embedded in their sequence are known as "HMG motif proteins."

Bioinformatics

Entrez	3150 Human
Uniprot	AAA52677 Human AAH23984 Human NM_004965 Human NP_004956 Human P05114 Human
Product By Gene ID	3150
Alternate Names	FLJ31471 High mobility group nucleosome-binding domain-containing protein 1 high-mobility group (nonhistone chromosomal) protein 14 high-mobility group nucleosome binding 1 high-mobility group nucleosome binding domain 1 HMG14FLJ27265 MGC104230 MGC117425 non-histone chromosomal protein HMG-14 nonhistone chromosomal protein HMG-14

Research Areas for HMGN1/HMG14

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Breast Cancer
Cancer
Cell Cycle and Replication
Checkpoint signaling
Chromatin Research
Core ESC-Like Genes
DNA Double Strand Break Repair
DNA Repair
Epigenetics
Histone Deacetylases
Phospho-Specific
Stem Cell Markers