Species: Hu, Po
Applications: WB, Flow, IP, CyTOF-ready
Host: Mouse Monoclonal
Description
HLA-DQB1 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of analpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system bypresenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells(APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains 6 exons.Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes thetransmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the betachain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 differentmolecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. (provided by RefSeq)
Bioinformatics
Product By Gene ID |
3119 |
Alternate Names |
- IDDM1
- CELIAC1
- HLA-DQB
- HLA class II histocompatibility antigen, DQ beta 1 chain
- MHC class II DQ beta chain
- MHC class II HLA-DQ beta glycoprotein
- MHC class II antigen DQB1
- MHC class II antigen HLA-DQ-beta-1
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Research Areas for HLA DQ1/DQ3
Find related products by research area and learn more about each of the different research areas below.
Adaptive ImmunityAsthmaImmunology
Bioinformatics Tool for HLA DQ1/DQ3
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