HLA DQ1/DQ3 Products

Description

HLA-DQB1 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of analpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system bypresenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells(APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains 6 exons.Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes thetransmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the betachain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 differentmolecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. (provided by RefSeq)

Bioinformatics

Product By Gene ID	3119
Alternate Names	CELIAC1 HLA class II histocompatibility antigen, DQ beta 1 chain HLA-DQB IDDM1 MHC class II antigen DQB1 MHC class II antigen HLA-DQ-beta-1 MHC class II DQ beta chain MHC class II HLA-DQ beta glycoprotein

Diseases related to HLA DQ1/DQ3

Discover more about diseases related to HLA DQ1/DQ3.

Diabetes Mellitus
Diabetes Mellitus, Insulin-dependent
Dysequilibrium Syndrome
Autoimmune Reaction
Autoimmune Diseases
Sclerosis
Autoimmunity
Malignant Neoplasms
Arthritis
Rheumatoid Arthritis
Multiple Sclerosis
Celiac Disease
Neoplasms
Diffuse Scleroderma
Diabetes Mellitus, Non-insulin-dependent
Infective Disorder
Hepatitis
Carcinoma
Lupus Erythematosus, Systemic
Malignant Tumor Of Cervix

Pathways for HLA DQ1/DQ3

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Pathogenesis
Immune Response
Lymphocyte Proliferation
Secretion
Hypersensitivity
Donor Selection
Insulin Secretion
Localization
Methylation
Dna Amplification
Cell Adhesion
Gene Conversion
Disease Resistance
Transport
Transposition
Cell Activation
T Cell Activation
Fertilization
Aging
Lung Development

Research Areas for HLA DQ1/DQ3

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Adaptive Immunity
Asthma
Immunology

PTMs for HLA DQ1/DQ3

Learn more about PTMs related to HLA DQ1/DQ3.

Cleavage
Citrullination
Methylation

Bioinformatics Tool for HLA DQ1/DQ3

Discover related pathways, diseases and genes to HLA DQ1/DQ3. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.