Histone H2Av Products

Description

Variant histones H2A are synthesized throughout the cell cycle and are very different from classical S-phase regulated H2A. H2AvD is vital for viability, but the exact function of variant histones H2A is not known. H2A is a core component of the nucleosome, an octamer containing two molecules each of H2A, H2B, H3 and H4. The octamer wraps approximately 146 bp of DNA. HsAvD is expressed both maternally and zygotically and is found in embryos through to adults (female only). The human homologue, H2AX, is phosphorylated by ATM protein kinase when double strand DNA breaks occur. In mouse, H2AX "knock out" mice have an increased incidence of cancer.

Bioinformatics

Uniprot	P08985 Drosophila
Product By Gene ID	43229
Alternate Names	CG5499 gene product from transcript CG5499-RA gamma-His2Av H2AX 5499 CG5499 CG5499-PA gamma-H2Av gamma-HIS2AV H2A.F/Z H2a.V H2A.Z H2av H2AV_DROM h2AvD H2AZ his His2 HIS2AV His2AvD HisH2Av Hist Hist2av Histone H2A variant l(3)05146 l(3)810 l(3)97Dd l(3)L1602

Research Areas for Histone H2Av

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Phospho-Specific