HERC6 Products

Description

The HERC6 gene encodes a E3 ubiquitin-protein ligase that accepts ubiquitin from an E2 ubiquitin-conjugating enzyme. The HECT domain is expected to stimulate the formation of a thioester with ubiquitin before transmitting it to a substrate. The protein exists in three isoforms: isoform 1 is 1,022 amino acids long at a mass of 115 kDA, isoform 2 is 986 kDA at 111 kDA, and isoform 3 is 306 amino acids long at 32 kDA. HERC6 interacts with genes NME2, HERC3, HERC4, UBQLN2, and NME1-NME2. HERC6 has been investigated regarding its role in angelman syndrome, meningitis, and malaria.

Bioinformatics

Entrez	55008 Human
Uniprot	NP_060382 Human Q8IVU3 Human
Product By Gene ID	55008
Alternate Names	potential ubiquitin ligase EC 6.3.2 HECT domain and RCC1-like domain-containing protein 6 EC 6.3.2.- FLJ20637 probable E3 ubiquitin-protein ligase HERC6 hect domain and RLD 6

Diseases related to HERC6

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Influenza
Endometrial Polyp
Stomatitis
Newcastle Disease
Vesicular Stomatitis

Pathways for HERC6

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Conjugation
Estrus
Localization
Insemination

PTMs for HERC6

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Isgylation

Bioinformatics Tool for HERC6

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