Heparanase/HPSE Products

Antibodies
Heparanase/HPSE Antibody
Heparanase/HPSE Antibody
NBP3-03846
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC
Host: Rabbit Polyclonal
Heparanase/HPSE Antibody
Heparanase/HPSE Antibody
NBP3-03694
Species: Hu, Mu, Rt
Applications: WB, ICC/IF
Host: Rabbit Polyclonal
Heparanase/HPSE Antibody
Heparanase/HPSE Antibody
NBP2-84064
Species: Hu, Mu, Rt, Po, Bv, Ca, Eq
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
Heparanase/HPSE Overexpressio ...
Heparanase/HPSE Overexpression Lysate
NBL1-11701
Species: Hu
Applications: WB
Proteins
Recombinant Human Active Hepa ...
Recombinant Human Active Heparanas...
7570-GH
Species: Hu
Applications: Enzyme Activity
Formulation Catalog # Availability Price  
Recombinant Mouse Active Hepa ...
Recombinant Mouse Active Heparanas...
9788-GH
Species: Mu
Applications: Enzyme Activity
Formulation Catalog # Availability Price  

Description

Heparanase is an endo-beta-D-glucuronidase, which degrades heparan sulfate side chains of heparan sulfate proteoglycans (HSPGs) in the extracellular matrix. Heparanase plays an important role in ECM degradation, facilitating the migration and extravasations of tumor cells and inflammatory leukocytes. Upon degradation, heparanase releases growth factors and cytokines that stimulate cell proliferation and chemotaxis. Heparanase is a heterodimer comprised of a 50 kDa subunit harboring the active site and an 8 kDa subunit. It is produced as a latent 65 kDa precursor and proteolytically processed to its active form. Heparanase is highly expressed in myeloid leukocytes (i.e. neutrophils) in platelets and in human placenta. Human heparanase was found to be upregulated in various types of primary tumors, correlating in some cases with increased tumor invasiveness and vascularity and with poor prospective survival.

Bioinformatics

Entrez Human
Uniprot Human
Product By Gene ID 10855
Alternate Names
  • Hpa1
  • Heparanase-1
  • HEP
  • Endo-glucoronidase
  • HPR1
  • EC 3.2
  • HPA1
  • HPSE1heparanase-1
  • HSE1heparanase exon10-deletion
  • HPAheparanase exon 9 and 10 deletion
  • endo-glucoronidase
  • heparanase

Research Areas for Heparanase/HPSE

Find related products by research area and learn more about each of the different research areas below.

Pancreatic Stem Cell Markers
Stem Cell Markers

PTMs for Heparanase/HPSE

Learn more about PTMs related to Heparanase/HPSE.

Cleavage
Phosphorylation
Reduction
Glycosylation

Bioinformatics Tool for Heparanase/HPSE

Discover related pathways, diseases and genes to Heparanase/HPSE. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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