Heparanase/HPSE Products

Heparanase/HPSE Antibody (4D7 ...
Heparanase/HPSE Antibody (4D7)
Species: Hu
Applications: WB, ELISA
Host: Mouse Monoclonal
Heparanase/HPSE Knockout HeLa ...
Heparanase/HPSE Knockout HeLa Cell...
Species: Hu
Applications: WB
Heparanase/HPSE Overexpressio ...
Heparanase/HPSE Overexpression Lysate
Species: Hu
Applications: WB
Recombinant Human Active Hepa ...
Recombinant Human Active Heparanas...
Species: Hu
Applications: Enzyme Activity
Formulation Catalog # Availability Price  
Recombinant Mouse Active Hepa ...
Recombinant Mouse Active Heparanas...
Species: Mu
Applications: Enzyme Activity
Formulation Catalog # Availability Price  


Heparanase is an endo-beta-D-glucuronidase, which degrades heparan sulfate side chains of heparan sulfate proteoglycans (HSPGs) in the extracellular matrix. Heparanase plays an important role in ECM degradation, facilitating the migration and extravasations of tumor cells and inflammatory leukocytes. Upon degradation, heparanase releases growth factors and cytokines that stimulate cell proliferation and chemotaxis. Heparanase is a heterodimer comprised of a 50 kDa subunit harboring the active site and an 8 kDa subunit. It is produced as a latent 65 kDa precursor and proteolytically processed to its active form. Heparanase is highly expressed in myeloid leukocytes (i.e. neutrophils) in platelets and in human placenta. Human heparanase was found to be upregulated in various types of primary tumors, correlating in some cases with increased tumor invasiveness and vascularity and with poor prospective survival.


Entrez Human
Uniprot Human
Product By Gene ID 10855
Alternate Names
  • Hpa1
  • Heparanase-1
  • HEP
  • Endo-glucoronidase
  • HPR1
  • EC 3.2
  • HPA1
  • HPSE1heparanase-1
  • HSE1heparanase exon10-deletion
  • HPAheparanase exon 9 and 10 deletion
  • endo-glucoronidase
  • heparanase

Research Areas for Heparanase/HPSE

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Pancreatic Stem Cell Markers
Stem Cell Markers

PTMs for Heparanase/HPSE

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Bioinformatics Tool for Heparanase/HPSE

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