HBP1 Products

Lysates
HBP1 Overexpression Lysate (D ...
HBP1 Overexpression Lysate (Denatu...
H00026959-T01
Species: Hu
Applications: WB
Proteins
Recombinant Human HBP1 Protei ...
Recombinant Human HBP1 Protein
H00026959-P01
Species: Hu
Applications: WB, ELISA, PA
RNAi
HBP1 RNAi
HBP1 RNAi
H00026959-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

The HMG-box protein-1 (HBP1) is a member of the HMG family of transcription factors, which are characterized by the presence of a conserved protein motif, the high mobility group (HMG) 1 box, that mediates DNA binding. HBP1 binds to the tumor suppressor proteins Rb and p130 and initiates cell cycle arrest. Terminal cell differentiation requires this initial cell cycle arrest followed by the coordinated expression of genes defined as tissue-specifc markers. Along with initiating the commitment to cell differentiation, the continued activity of HBP1 abrogates the expression of tissue-specific genes by associating with the MyoD proteins. In muscle cell differentiation, the MyoD family of transcription factors, which include Myf5, MyoD and myogenein, induce the expression of these cell-type specific proteins and contribute to the development of cell phenotypes. The progression of terminal differentiation is, therefore, dependent on both a decrease in HBP1 activity and the corresponding activation of MyoD-induced gene transcription.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Product By Gene ID 26959
Alternate Names
  • USMCC2
  • FLJ16340
  • HMG-box containing protein 1
  • HMG box transcription factor 1
  • HMG box-containing protein 1
  • High mobility group box transcription factor 1
  • HMG-box transcription factor 1

Bioinformatics Tool for HBP1

Discover related pathways, diseases and genes to HBP1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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