HACE1 Products

Antibodies
HACE1 Antibody
HACE1 Antibody
NBP2-58757
Species: Hu, Mu, Rt
Applications: ICC/IF
Host: Rabbit Polyclonal
HACE1 Antibody
HACE1 Antibody
NBP1-55062
Species: Hu
Applications: WB
Host: Rabbit Polyclonal
HACE1 Antibody (2B3)
HACE1 Antibody (2B3)
H00057531-M04
Species: Hu
Applications: ELISA
Host: Mouse Monoclonal
Lysates
HACE1 Overexpression Lysate ( ...
HACE1 Overexpression Lysate (Native)
NBL1-11433
Applications: WB
Proteins
Recombinant Human HACE1 Prote ...
Recombinant Human HACE1 Protein
H00057531-Q01
Species: Hu
Applications: WB, ELISA, PA
HACE1 Recombinant Protein Ant ...
HACE1 Recombinant Protein Antigen
NBP2-58757PEP
Species: Hu
Applications: AC
RNAi
HACE1 RNAi
HACE1 RNAi
H00057531-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

The HACE1 gene codes for a E3 ubiquitin-protein ligase HACE1 that is a participant in Golgi membrane fusion as well as in regulation of small GTPases to mediate ubiquitination and degradation of active RAC1, working in defense against pathogens. This protein may also play a role as a transcription regulator through its interaction with RARB. HACE1 exists in four isoforms: isoform 1 is 909 amino acids long, 102 kDA; isoform 2 is 318 amino acids long, 35 kDA; isoform 3 is 562 amino acids long, 63 kDA; isoform 4 is 694 amino acids long, nearly 78 kDA. HACE1 has been researched in regards to celiac disease, malaria, colorectal cancer, wilms tumors, and carcinoma. It is involved in the SMAD signaling network as well as ubiquitin-proteasome dependent proteolysis and has been known to interact with genes RARA, RAB4A, RAC1, PLXNA2, and IRF7.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Product By Gene ID 57531
Alternate Names
  • EC 6.3.2
  • HACE
  • HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1
  • KIAA1320EC 6.3.2.-
  • E3 ubiquitin-protein ligase HACE1
  • HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1

Pathways for HACE1

View related products by pathway and learn more about each of the pathways below.

Cell Cycle
Methylation
Cell Division
Mrna Transcription
Membrane Fusion
Golgi Disassembly
Pathogenesis
Virulence
Cell Cycle Arrest

PTMs for HACE1

Learn more about PTMs related to HACE1.

Methylation
Phosphorylation

Bioinformatics Tool for HACE1

Discover related pathways, diseases and genes to HACE1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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