HACE1 Products

Description

The HACE1 gene codes for a E3 ubiquitin-protein ligase HACE1 that is a participant in Golgi membrane fusion as well as in regulation of small GTPases to mediate ubiquitination and degradation of active RAC1, working in defense against pathogens. This protein may also play a role as a transcription regulator through its interaction with RARB. HACE1 exists in four isoforms: isoform 1 is 909 amino acids long, 102 kDA; isoform 2 is 318 amino acids long, 35 kDA; isoform 3 is 562 amino acids long, 63 kDA; isoform 4 is 694 amino acids long, nearly 78 kDA. HACE1 has been researched in regards to celiac disease, malaria, colorectal cancer, wilms tumors, and carcinoma. It is involved in the SMAD signaling network as well as ubiquitin-proteasome dependent proteolysis and has been known to interact with genes RARA, RAB4A, RAC1, PLXNA2, and IRF7.

Bioinformatics

Entrez	57531 Human
Uniprot	NM_020771 Human NP_065822 Human Q8IYU2 Human
Product By Gene ID	57531
Alternate Names	E3 ubiquitin-protein ligase HACE1 EC 6.3.2 HACE HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1 HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1 KIAA1320EC 6.3.2.-