GSTM4 Products

Description

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds. Multiple transcript variants, each encoding a distinct protein isoform, have been identified. [provided by RefSeq]

Bioinformatics

Entrez	2948 Human
Uniprot	NP_000841.1 Human
Product By Gene ID	2948
Alternate Names	EC 2.5.1.18 glutathione S-alkyltransferase M4 glutathione S-aralkyltransferase M4 glutathione S-aryltransferase M4 glutathione S-transferase M4 glutathione S-transferase mu 4 GST class-mu 4 GSTM4-4 GST-Mu2 GTM4 GTS-Mu2 MGC131945 MGC9247 S-(hydroxyalkyl)glutathione lyase M4

Research Areas for GSTM4

Find related products by research area and learn more about each of the different research areas below.

Cancer
Signal Transduction