GRB 14 Products

Description

Many growth factors function by binding receptors with intrinsic tyrosine kinase activity. Signaling by such receptors involves a series of intermediates characterized by SH2 domains that bind tyrosine phosphorylated receptors by a direct interaction between the SH2 domain and specific phosphotyrosine-containing receptor sequences. GRB7, a SH2 domain protein, has a single SH2 domain at its C-terminal, a central region with similarity to Ras GAP and a proline-rich N terminus. A related SH2 domain-containing protein, GRB10, exhibits a high degree of homology with GRB7. GRB10 undergoes serine but not tyrosine phosphorylation in response to EGF treatment, but appears to bind to the EGF receptor poorly. An additional member of the GRB7 family, designated GRB 14, contains a pleckstrin homology domain in its central region and a carboxy terminal SH2 domain.

Bioinformatics

Entrez	2888 Human 50915 Mouse 58844 Rat
Uniprot	Q14449 Human
Product By Gene ID	2888
Alternate Names	GRB14 adapter protein growth factor receptor-bound protein 14

Research Areas for GRB 14

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Signal Transduction