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GPR1 is an Orphan-A GPCR with an unknown ligand. GPR1 was identified in a search for genes responsible for mediating brain reward and may have a role in drug addiction. It has also been shown to act as an HIV coreceptor in kidney mesangial cells (Tokizawa et al., 2000). GPR1 has been reported to be expressed in brain and kidney. ESTs have been isolated from placenta and thymus libraries. Caution: GPR1 should be distinguished from the yeast protein of the same name.
