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Glia maturation factor gamma (GMF-gamma) is a cytokine-responsive protein in erythropoietin-induced and granulocyte-colony stimulating factor-induced hematopoietic lineage development. Also Glia maturation factor is a nerve growth factor implicated in nervous system development, angiogenesis and immune function. GMF-gamma possesses hematopoietic tissue-specific gene expression, a promoter concentrated with high-score hematopoiesis-specific transcription factors, and possible molecular coevolution with a rudimentary blood/immune system. Recombinant human GMF-gamma protein, was expressed in E.coli and purified by using conventional chromatography techniques.
