Glucuronosyltransferase 1A1/UGT1A1 Products

Description

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome. [provided by RefSeq]

Bioinformatics

Product By Gene ID

54658

Alternate Names

bilirubin UDP-glucuronosyltransferase 1-1 bilirubin UDP-glucuronosyltransferase isozyme 1 Bilirubin-specific UDPGT isozyme 1 GNT1 GNT1EC 2.4.1.17 HUG-BR1 UDP glucuronosyltransferase 1 family, polypeptide A1 UDP glycosyltransferase 1 family, polypeptide A1 UDP-glucuronosyltransferase 1-1 UDP-glucuronosyltransferase 1-A UDP-glucuronosyltransferase 1A1 UDPGT 1-1 UDPGT UG-BR1 UGT1 UGT1*1 UGT1.1 UGT1-01 UGT1A UGT-1A UGT1A1 UGT1AUDPGT 1-1 UGT1BILIQTL1

Research Areas for Glucuronosyltransferase 1A1/UGT1A1

Find related products by research area and learn more about each of the different research areas below.

Signal Transduction