Galanin Products

Description

Galanin is a 29/30 amino acid neuropeptide widely distributed in the peripheral and central nervous systems and endocrine system. The amino acid sequence of galanin is very conserved (almost 90% among species), indicating the importance of the molecule. In the brain, the highest concentrations are observed in the hypothalamus and particularly in the nerve terminals of the median eminence. There are three well-characterized G-protein coupled galanin receptors subtypes (GalR1-3). A more recently discovered 60 amino acid galanin-like peptide (GALP) shares amino acid sequence homology with galanin (1-13) in position 9-21 and has high binding affinity for GalR1-3, with highest affinity for GalR3. The fact that Galanin has a wide spectrum of activities indicates that it is an important messenger for intercellular communication within the nervous system and the neuroendocrine axis. Both galanin and GALP are implicated in the regulation of food and water intake behavior, and many related neuroendocrine functions.

Bioinformatics

Entrez	51083 Human
Product By Gene ID	51083
Alternate Names	GAL GAL1 galanin prepropeptide Galanin GALN GALNgalanin-related peptide GLNNgalanin-message-associated peptide GMAP MGC40167

Research Areas for Galanin

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Neuroscience