Galactose-3-O-sulfotransferase 2/GAL3ST2 Products

Description

Galactose-3-O-sulfotransferase 2 (GAL3ST2) is a type II Golgi resident transmembrane protein. It transfers sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to the C-3 hydroxyl group of nonreducing beta -galactosyl residues present on various glycans, such as N-acetyllactosamine, lactose, lacto-N-tetraose (Lc4), lacto-N-neotetraose (nLc4), type 1 oligosaccharides (Gal beta 1-3GlcNAc-R), type 2 oligosaccharides (Gal beta 1-4GlcNAc-R), and core 1 O-glycans (Gal beta 1-3GalNAc alpha 1-Ser/Thr) (1). Given its broad substrate specificity, GAL3ST2 is capable of radioisotope labeling of non-reducing terminal galactose on glycoproteins or glycolipids with ³⁵S. In addition, it can be used to generate galactin-4 and galactin-8 specific ligands (2, 3). The protein is widely expressed in various tissues (1). The enzymatic activity of the recombinant human GAL3ST2 is measured using a phosphatase-coupled assay (4).

Bioinformatics

Uniprot	Q9H3Q3 Human
Product By Gene ID	64090
Alternate Names	GAL3ST2 GAL3ST-2 Galactose-3-O-sulfotransferase 2 GP3ST