G2A/GPR132 Products

Antibodies
G2A/GPR132 Antibody
G2A/GPR132 Antibody
NBP1-89808
Species: Hu
Applications: ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
G2A/GPR132 Antibody
G2A/GPR132 Antibody
NBP1-89807
Species: Hu
Applications: ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
G2A/GPR132 Antibody
G2A/GPR132 Antibody
NLS3702
Species: Hu, Monkey
Applications: IHC-P
Host: Rabbit Polyclonal
Proteins
G2A/GPR132 Recombinant Protei ...
G2A/GPR132 Recombinant Protein Ant...
NBP1-89808PEP
Species: Hu
Applications: AC
G2A/GPR132 Recombinant Protei ...
G2A/GPR132 Recombinant Protein Ant...
NBP1-89807PEP
Species: Hu
Applications: AC
G2A/GPR132 Recombinant Protei ...
G2A/GPR132 Recombinant Protein
H00029933-G01
Species: Hu
RNAi
G2A/GPR132 RNAi
G2A/GPR132 RNAi
H00029933-R02
Species: Hu
Applications: RNAi, RNAi SP

Description

GPR132, also known as G2A (for G2 accumulation), is a seven transmembrane G protein-coupled receptor that is upregulated in response to DNA damage and stress. G2A is predominantly expressed in hematopoietic tissues and in hematopoietic stem cells, and it is more highly detected in pro-B cells, while lower expression is observed in immature B cells and pre-B cells. G2A is expressed throughout T cell maturation, and it is further increased in response to T-cell activation. Ectopic expression of a G2A fusion protein in NIH/3T3 fibroblasts induces a cell cycle arrest that is consistent with a block at the G2/M transition. G2A is also able to attenuate the proliferative effects of Bcr-Abl, a chimeric tyrosine kinase oncogene, suggesting that G2A possesses anti-oncogenic properties. The amino acid sequence of G2A contains a destruction box motif that is consistently observed in cyclins, where it is required for ubiquitination and proteolytic degradation.

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Product By Gene ID 29933
Alternate Names
  • MGC99642
  • probable G-protein coupled receptor 132
  • G2 accumulation protein
  • G2AG protein-coupled receptor G2A
  • G protein-coupled receptor 132

Diseases related to G2A/GPR132

Discover more about diseases related to G2A/GPR132.

Atherosclerosis
Diabetes Mellitus
Myocardial Infarction
Infarction
Cerebrovascular Accident
Dental Plaque

Pathways for G2A/GPR132

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Macrophage Differentiation
Secretion

Research Areas for G2A/GPR132

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GPCR

Bioinformatics Tool for G2A/GPR132

Discover related pathways, diseases and genes to G2A/GPR132. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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